Whereas continuous exposure to all three

2018-10-22

Whereas continuous exposure to all three factors (4+) resulted in higher levels of DE genes, there was no significant difference in the proportion of Foxa2+Sox17+ cysteine protease when compared to transient Wnt activation (2+2−). Surprisingly, T expression in a fraction of differentiated cells was

Inefficient DNA DSB repair can promote genomic rearrangement

2018-10-20

Inefficient DNA DSB repair can promote genomic rearrangements which can lead to malignant transformations (Reya et al., 2001) thus leading to the notion that stem cells with compromised genome integrity commit altruistic suicide or differentiate, and are more sensitive to DNA damage than other cells

Interestingly the migration kinetics of

2018-10-20

Interestingly, the migration kinetics of type B astrocytes was similar to that previously described for neuroblasts (Elvira et al., 2012). This suggests that both cell types are able to respond to the same “damage signals” and that type B astrocytes could help in neuroblast migration as previously s

Host pathogen interaction is a balancing

2018-10-20

Host-pathogen interaction is a balancing act as viruses evolved to have strategies to evade the host defense system. HCV NS3, core and NS5A proteins are involved in immune evasion by modulating specific and innate immune pathways (Basu et al., 2001; Horner and Gale, 2013). NS3 protease can effective

The negative regulation of Zac expression by SOXB

2018-10-20

The negative regulation of Zac1 expression by SOXB1 transcription factors combined with the decrease of Sox2 expression as the levels of Zac1 increase suggest that ZAC1 and SOXB1 factors could act as a cross-repressive genetic switch governing the acquisition of distinct cellular identities (Enver e

The first line of treatment for the majority of primary

2018-10-20

The first-line of treatment for the majority of primary malignant molecular weight calculator tumors is maximal safe resection followed by radiation therapy, with or without chemotherapy, based on numerous studies that demonstrate a survival benefit with the addition of radiation (Stupp et al., 200

br Resource table br Resource details Spastic paraplegia

2018-10-20

Resource table Resource details Spastic paraplegia gene type 5 (SPG5) is an autosomal recessive subtype of hereditary spastic paraplegia caused by mutations in CYP7B1, a gene encoding for the cytochrome P-450 oxysterol 7-α-hydroxylase, essential for the liver-specific alternative pathway in bi

To derive hiPSC from patient fibroblasts we adopted

2018-10-20

To derive hiPSC from patient fibroblasts, we adopted previous protocols (Okita et al., 2011; Rasmussen et al., 2014) and electroporated the patient\'s skin fibroblasts with episomal plasmids expressing human OCT4, SOX2, L-MYC, KLF4, NANOG, LIN28, and short hairpin RNA against TP53. To demonstrate th

br Materials and methods br Author disclosure statement br A

2018-10-20

Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of China to SZ (fund number: 30400447) and HW (fund number: 30500548). Resource table. Resource details To engineer a biallelic mutation in

Although we utilized two hiPSC

2018-10-20

Although we utilized two hiPSC lines derived from two different types of somatic cells, specifically skin fibroblasts (eKA3) and peripheral blood mononuclear naloxone hydrochloride (Ff-I01), obtained from independent donors, the immune responses mediated by hiPSC-NS/PCs were similar between the two

Our work implicates exosomes and the miRNAs they

2018-10-20

Our work implicates exosomes, and the miRNAs they contain, as crucial mediators of CDC-induced cardiac regeneration. CDCs exert diverse but coordinated effects: they recruit endogenous progenitor chenodeoxycholic acid and coax surviving heart cells to proliferate (Chimenti et al., 2010; Li et al., 2

Numerous morphogenetic events are explained by the cell surf

2018-10-20

Numerous morphogenetic events are explained by the cell surface tension model. In equilibrium, surface tension is minimized via coordinated forces generated by cell surface tension and actomyosin-mediated cortical tension, resulting in cell sorting and self-organization (Beysens et al., 2000; Heisen

RNA seq of SCs reinforced

2018-10-20

RNA-seq of SCs reinforced transcriptional dynamics observed from whole tissues, whereby in the early period, immune-response and chemokine transcripts were upregulated, followed by proliferation and differentiation during the middle time period. Several TFs associated with quiescent biotin-LC-LC-tyr

Hello world!

2018-07-29